Hydrochloric Acid → HCID 13221061, compound

Participants

Reaction Conditions

Reaction Steps

1.8 mL (11.4 mmol) triethylsilane was added to a solution of 1.45 g (5.7 mmol, crude product from 5.1) benzoic acid [1-(2-methoxyphenyl)methylidene]hydrazide in 10 mL trifluoroacetic acid at 0° C., then the mixture was stirred, first for 2 hr at 0° C. and then for 4 hr at room temperature. The yellow reaction solution was then combined with 120 mL 2 N HCl and extracted with methylene chloride, and the organic phase was then shaken with 1 N NaOH, dried with Na2SO4, and concentrated on a rotary evaporator. Stirring in diisopropyl ether and subsequent drying resulted in approximately 1.1 g product in the form of a white solid.

Provenance & Evidence