Hydrochloric Acid → HCID 178489479, compound

Participants

Reaction Conditions

Reaction Steps

Benzoic acid N′-(2-methoxybenzyl)hydrazide (200 mg, 0.78 mmol from 5.2) was dissolved in a mixture of 1.5 mL dioxane and 1 mL water, combined with 164 mg (3.9 mmol) cyanamide dissolved in 1 mL water, adjusted to pH 2 with 1 N HCl, then stirred for 4 hr at 120° C. in a microwave oven at 200 watts power. The pH was checked every 30 minutes and readjusted to pH 2 as necessary. The resulting solid was then suctioned off, washed with a small quantity of diethyl ether, and dried (65 mg target product in the form of a light yellow solid).

Provenance & Evidence