4-(Propan-2-yl)benzene-1-sulfonyl chloride → HCID 16045797, compound

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Reaction Steps

55.1 A solution of 100 mg 4-(3-aminophenyl)-1-(2-methoxybenzyl)-1H-imidazole-2-ylamine (0.34 mmol, Example 51) in 3 mL pyridine was combined with 74 mg 4-isopropylbenzenesulfonic acid chloride at 0° C., then stirred for 18 hr at room temperature. The batch was then diluted with methylene chloride, extracted with 1 M NaOH and with water, and the organic phase was then dried (Na2SO4) and concentrated, and the residue thus obtained was stirred in acetic ethyl ester, suctioned off, and dried (130 mg target product).

Provenance & Evidence