4'-Chloro-3'-nitroacetophenone → HCID 89897925, compound

Participants

Reaction Steps

Ammonium acetate (3.86 g, 50 mmol), NaBH3CN (0.22 g, 3.5 mmol), and 3 Å molecular sieves (25 g) were added to a mixture of 4-chloro-3-nitroacetophenone (1.00 g, 5 mmol) in MeOH (15 mL) at rt. The mixture was stirred at rt for 20 h and NaHCO3 (aq, sat) and EtOAc were added. The mixture was filtered and the aq layer washed with EtOAc. The combined organic phases were dried over Na2SO4 and concentrated to give the sub-title compound. Yield: 0.27 g (27%).

Provenance & Evidence