反应详情

A mixture of 3-Nitro-4-methylaminobenzoic acid (196 mg, 1.00 mmol), 20 ml DCM, 0.15 ml pyridine and 160 mg 1-Chloro-N,N,2-trimethylprop-1-enylamine was stirred until a clear solution was obtained. 4-Bromoaniline (172 mg, 1.0 mmol) was added and the mixture was stirred for 16 h. The mixture was filtered through a pad of ALOX B and concentrated. 5 ml DMF and 20 ml H2O were added and the precipitate was collected and dried. Yield: 240 mg (68%).

1. customwas obtained
2. stirringthe mixture was stirred for 16 h
3. filtrationThe mixture was filtered through a pad of ALOX B
4. concentrationconcentrated
5. addition5 ml DMF and 20 ml H2O were added
6. customthe precipitate was collected
7. customdried