Pivaloyl chloride → HCID 178468557, compound

Participants

Reaction Steps

A mixture of Ethyl-2-[5-(aminomethyl)-2-chlorophenylamino]-6-chloro-benzimidazole-5-carboxylate (1.00 g, 2.4 mmol), pivaloyl chloride (0.296 ml, 2.4 mmol), 1.5 ml TEA and 50 ml THF were stirred for 18 h at rt. The mixture was concentrated, diluted with EtOAc, washed 2× with H2O, dried over Na2SO4 and concentrated. The residue was purified by chromatography to give the sub-title compound. Yield 0.92 g (83%).

Provenance & Evidence