Sodium Hydroxide → HCID 178447317, compound

Participants

Reaction Steps

A mixture of Ethyl-2-[5-(tert.butylcarbonylaminomethyl)-2-chlorophenylamino]-6-chloro-benzimidazole-5-carboxylate (0.91 g, 1.9 mmol) in 20 ml EtOH was treated with 1 N NaOH (3.9 ml+0.98 ml+0.98 ml) for 4 h at rt, for 5 h at 50° C. and for 3 d at rt. The mixture was concentrated, diluted with H2O, acidified with 1 N HCl and cooled in an ice bath. The precipitate was filtered, washed with ice water and dried to give the sub-title compound. Yield 0.81 g (95%).

Provenance & Evidence