HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyldiazomethane → Methyl 3-bromo-5-(hydroxymethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | 3-Bromo-5-(hydroxymethyl)benzoic acid | HCID 8167127 | — |
| Solvent | Benzene methanol | HCID 21927730 | — |
| Product | Methyl 3-bromo-5-(hydroxymethyl)benzoate | HCID 11356988 | — |
Reaction Steps
To 3-bromo-5-(hydroxymethyl)benzoic acid (7.0 g, 30 mmol) in 20% methanol/benzene (100 mL) is added trimethylsilyldiazomethane (2M in hexanes), and the reaction is stirred 16 h. The reaction is concentrated under reduced pressure to afford the title compound. ESI MS m/z 244.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727997B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-a362f1bc326742dc8cca9713458fb263 |
| Source note | uspto-grants-2010_06 |