HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(Aminomethyl)-2-chloroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Amino-4-chlorobenzonitrile | HCID 104464 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(Aminomethyl)-2-chloroaniline | HCID 13465097 | — |
Reaction Steps
A mixture of 3-Amino-4-chloro-benzonitrile (1.32 g, 8.33 mmol), Ra-Nickel (0.25 g) and 80 ml NH3 in MeOH was stirred for 4 h at rt under H2-atmosphere (3 bar). The mixture was filtered and concentrated and the sub-title compound was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921405B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-5a3bb122349746c6a1bc91a430c324ba |
| Source note | uspto-grants-2014_12 |