HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Thiocarbonyldiimidazole → N-(4-Chloro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Thiocarbonyldiimidazole | HCID 80264 | — |
| Reactant | N-(3-amino-4-chlorobenzyl)-1-(trifluoromethyl)cyclopropanecarboxamide | HCID 59529866 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(4-Chloro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide | HCID 86646336 | — |
Reaction Steps
A solution of N-(3-amino-4-chlorobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide (5.21 g; 17.79 mmol) in DCM (40 mL) was added to a solution of TCDI (3.80 g; 21.34 mmol) in DCM (30 mL) at 0° C. After 12 h at rt, the mixture was concentrated and the residue was purified by column chromatography to give the sub-title compound. Yield: 5.00 g (84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921405B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-4f47b4f1957642a990fc6f3d70946c34 |
| Source note | uspto-grants-2014_12 |