Nitric Acid → Ethyl 2,4-difluoro-5-nitrobenzoate

Participants

Reaction Steps

Conc. HNO3 (8 mL) was added dropwise to a mixture of ethyl 2,4-difluorobenzoate (10.0 g; 53.7 mmol) in cone. H2SO4 (8 mL) at 0° C. After 2 h at 0° C., the mixture was poured onto ice and extracted with EtOAc. The organic extracts were washed with saturated NaHCO3 solution (aq) and concentrated to give the sub-title compound. Yield: 11.8 g (95%).

Provenance & Evidence