HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1410225Generated: November 1, 2026
1,1'-Thiocarbonyldiimidazole → N-(4-Fluoro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide
https://huagongshe.com/reaction/1410225
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,1'-Thiocarbonyldiimidazole | HCID 80264 | — |
| Reactant | N-(3-Amino-4-fluorobenzyl)-1-(trifluoromethyl)cyclopropanecarboxamide | HCID 59529824 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(4-Fluoro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide | HCID 86646337 | — |
Reaction Steps
A mixture of N-(3-amino-4-fluorobenzyl)-1-(trifluoromethyl)cyclopropanecarboxamide (3.17 g; 11.5 mmol) and TCDI (3.07 g; 17.2 mmol) in DCM (50 mL) was heated over night at 50° C. The mixture was concentrated and the residue purified by column chromatography to give the sub-title compound. Yield: 3 g (82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08921405B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-d248b5c7236d44b5ae486fbdf48271cd |
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| Source note | uspto-grants-2014_12 |
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