4-Bromoaniline → N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzamide

Participants

Role	Name	HCID	Charge
Reactant	4-Bromoaniline	HCID 7807	—
Reactant	Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 2733084	—
Reactant	2-(2,2-Difluoroethoxy)-4-(methylamino)-5-nitrobenzoic acid	HCID 59529854	—
Solvent	Dimethylformamide	HCID 6228	—
Product	N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzamide	HCID 59529852	—

Reaction Steps

The sub-title compound was prepared in accordance with Example 72, step (c) using 2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzoic acid (800 mg; 2.90 mmol), 4-bromoaniline (499 mg; 2.90 mmol), HBTU (1.10 g; 2.90 mmol), TEA (587 mg; 5.80 mmol) and DMF (15 mL). Yield: 1.01 g (81%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08921405B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-3e98a095978440038ad997a9b8de99e7
Source note	uspto-grants-2014_12