HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromoaniline → 4-amino-N-(4-bromophenyl)-2-methoxy-5-nitrobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromoaniline | HCID 7807 | — |
| Reactant | 4-Amino-2-methoxy-5-nitrobenzoic acid | HCID 101016 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-amino-N-(4-bromophenyl)-2-methoxy-5-nitrobenzamide | HCID 59529801 | — |
Reaction Steps
The sub-title compound was prepared in accordance with the procedure in Example 59, step (a) using 4-amino-2-methoxy-5-nitrobenzoic acid (2.0 g; 9.43 mmol), TBTU (3.33 g; 10.4 mmol), TEA (2.9 mL; 20.8 mmol), 4-bromoaniline (1.62 g; 9.43 mmol) and DMF (70 mL). Yield: 3.41 g (99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921405B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-ab75c8931ea84422b8d4b088babcb46d |
| Source note | uspto-grants-2014_12 |