HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1410250Generated: November 3, 2026
Ammonia → 3-Amino-4-(trifluoromethyl)benzonitrile
https://huagongshe.com/reaction/1410250
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Fluoro-4-(trifluoromethyl)benzonitrile | HCID 2737550 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | 3-Amino-4-(trifluoromethyl)benzonitrile | HCID 52987954 | — |
Reaction Steps
A closed pressure tube charged with 3-fluoro-4-(trifluoromethyl)benzonitrile (10.0 g; 52.9 mmol) and liquid NH3 (60 mL) was heated for 6 days at 90° C. The tube was cooled to −60° C. and opened. The mixture was allowed to stir for 1 h at rt. The residue was treated with brine and extracted with EtOAc to give the crude sub-title compound (10.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08921405B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-0b0a8f1c00404c8cabb803ff9980c599 |
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| Source note | uspto-grants-2014_12 |
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