HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylcarbodiimide → Ethyl 2-(2-chloro-5-{[(tert.butylcarbonyl)amino]methyl}phenylamino)-6-(2,2-difluoroethoxy)-1-methyl-1H-benzo[d]imidazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | Ethyl 2-(2,2-difluoroethoxy)-4-methylamino-5-amino-benzoate | HCID 59529827 | — |
| Reactant | HCID 86646343 | HCID 86646343 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-(2-chloro-5-{[(tert.butylcarbonyl)amino]methyl}phenylamino)-6-(2,2-difluoroethoxy)-1-methyl-1H-benzo[d]imidazole-5-carboxylate | HCID 59529856 | — |
Reaction Steps
The sub-title compound was prepared from ethyl 2-(2,2-difluoroethoxy)-4-methylamino-5-amino-benzoate and N-(4-chloro-3-isothiocyanatobenzyl)-2,2-dimethylpropionamide with DIC in DMF at r.t. in analogy to example 72a. The crude material was directly used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921405B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-afbcff8857064843915688c3a6ac2719 |
| Source note | uspto-grants-2014_12 |