HCID 178418361, compound → HCID 178482270, compound

HRID 1410267Notes

Reaction equation

HRID 1410267 reaction equation
[N+:1]([C:4]1[C:5]([NH:28][CH3:29])=[CH:6][C:7]([O:23][CH2:24][CH:25]([F:27])[F:26])=[C:8]([CH:22]=1)[C:9]([NH:11][C@H:12]1[CH2:17][CH2:16][C@H:15]([C:18]([F:21])([F:20])[F:19])[CH2:14][CH2:13]1)=[O:10])([O-])=O.[H][H]>[Pd]>[NH2:1][C:4]1[C:5]([NH:28][CH3:29])=[CH:6][C:7]([O:23][CH2:24][CH:25]([F:26])[F:27])=[C:8]([CH:22]=1)[C:9]([NH:11][C@H:12]1[CH2:13][CH2:14][C@H:15]([C:18]([F:21])([F:20])[F:19])[CH2:16][CH2:17]1)=[O:10]

Participants

4

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178482271HCID 178482271, compound

Product 1

HCID 178482270HCID 178482270, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The sub-title compound was prepared from 5-nitro-2-(2,2-difluoroethoxy)-4-(methylamino)-N-(trans-4-trifluoromethyl-cyclohex-1-yl)-benzamide, hydrogen and Pd/C in analogy to example 86c.

Sources & evidence

ORD record
ord-40496cb079c94313aa102903498bbdc1
Source dataset
uspto-grants-2014_12
Patent number
US08921405B2

Reaction notes

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