HCID 178447313, compound → HCID 178481211, compound

HRID 1410268Notes

Reaction equation

HRID 1410268 reaction equation
[NH2:1][C:2]1[C:3]([NH:26][CH3:27])=[CH:4][C:5]([O:21][CH2:22][CH:23]([F:25])[F:24])=[C:6]([CH:20]=1)[C:7]([NH:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([C:16]([F:19])([F:18])[F:17])[CH2:12][CH2:11]1)=[O:8].[N:28]([C:31]1[CH:32]=[C:33]([CH:42]=[CH:43][C:44]=1[C:45]([F:48])([F:47])[F:46])[CH2:34][N-:35][C:36](=[O:41])[C:37]([CH3:40])([CH3:39])[CH3:38])=[C:29]=S>>[F:17][C:16]([F:18])([F:19])[C@H:13]1[CH2:14][CH2:15][C@H:10]([NH:9][C:7]([C:6]2[C:5]([O:21][CH2:22][CH:23]([F:24])[F:25])=[CH:4][C:3]3[N:26]([CH3:27])[C:29]([NH:28][C:31]4[CH:32]=[C:33]([CH2:34][NH:35][C:36]([C:37]([CH3:40])([CH3:39])[CH3:38])=[O:41])[CH:42]=[CH:43][C:44]=4[C:45]([F:48])([F:47])[F:46])=[N:1][C:2]=3[CH:20]=2)=[O:8])[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 178447313HCID 178447313, compoundHCID 178482270HCID 178482270, compound

Product 1

HCID 178481211HCID 178481211, compoundYield 51%

Procedure

The sub-title compound was prepared from 5-amino-2-(2,2-difluoroethoxy)-4-(methylamino)-N-(trans-4-trifluoromethyl-cyclohex-1-yl)-benzamide and N-(3-isothiocyanato-4-trifluoromethyl-benzyl)-pivaloylamide in analogy to example 72a.

Sources & evidence

ORD record
ord-92ee9df17a85494280ad956b071433c2
Source dataset
uspto-grants-2014_12
Patent number
US08921405B2

Reaction notes

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