HCID 178507678, compound → HCID 178507677, compound

HRID 1410270Notes

Reaction equation

HRID 1410270 reaction equation
[N+:1]([C:4]1[C:5]([NH2:24])=[CH:6][C:7]([Cl:23])=[C:8]([CH:22]=1)[C:9]([NH:11][C@H:12]1[CH2:17][CH2:16][C@H:15]([C:18]([F:21])([F:20])[F:19])[CH2:14][CH2:13]1)=[O:10])([O-])=O>[Ni]>[NH2:24][C:5]1[C:4]([NH2:1])=[CH:22][C:8]([C:9]([NH:11][C@H:12]2[CH2:13][CH2:14][C@H:15]([C:18]([F:19])([F:20])[F:21])[CH2:16][CH2:17]2)=[O:10])=[C:7]([Cl:23])[CH:6]=1

Participants

3

Reactant 1

HCID 178507678HCID 178507678, compound

Product 1

HCID 178507677HCID 178507677, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

5-Nitro-2-chloro-4-amino-N-(trans-4-trifluoromethyl-cyclohex-1-yl)-benzamide was hydrogenated with Ra—Ni in analogy to example 66g. The crude material was directly used without further purification.

Workup

  1. customThe crude material was directly used without further purification

Sources & evidence

ORD record
ord-7ac3bf9cd99d4bd9bdacd9e4fec82bdc
Source dataset
uspto-grants-2014_12
Patent number
US08921405B2

Reaction notes

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