Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dronedarone Hydrochloride | HCID 219025 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Dronedarone | HCID 208898 | — |
Reaction Steps
1 part by weight of dronedarone hydrochloride and 3.0 parts by weight of Povidone PVP K-30 were weighted, and then 12 parts by weight of dichloromethane were added, and stirred until the solution became clarified. The solution was spray dried and at the same time the inlet and outlet temperatures of the spray drier (Mini Spray Dryer, B290, Buchi, Switzerland) were maintained at 90° C. and 55° C. respectively. Then the sample was collect and the solid dispersion of dronedarone was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08921416B2 |
|---|
| Source dataset | uspto-grants-2014_12 |
|---|
| ORD ID | ord-2ae323042e914fad94ff2650316856cb |
|---|
| Source note | uspto-grants-2014_12 |
|---|
