N-Methyloxindole → HCID 178481470, compound

HRID 1410347Notes

Reaction equation

HRID 1410347 reaction equation
[I:1][C:2]1[C:10]2[C:5](=[CH:6][C:7](/[CH:11]=[C:12]3/[C:13](=[O:21])[NH:14][C:15]4[C:20]/3=[CH:19][CH:18]=[CH:17][CH:16]=4)=[CH:8][CH:9]=2)[NH:4][N:3]=1.I[C:23]1C2C(=CC(C=O)=CC=2)NN=1.CN1C2C(=CC=CC=2)CC1=O>>[I:1][C:2]1[C:10]2[C:5](=[CH:6][C:7](/[CH:11]=[C:12]3/[C:13](=[O:21])[N:14]([CH3:23])[C:15]4[C:20]/3=[CH:19][CH:18]=[CH:17][CH:16]=4)=[CH:8][CH:9]=2)[NH:4][N:3]=1

Participants

4

Reactant 3

HCID 6096N-MethyloxindoleHCID 178517058HCID 178517058, compoundHCID 178519327HCID 178519327, compound

Product 1

HCID 178481470HCID 178481470, compound

Procedure

According to the method described for (E)-3-((3-iodo-1H-indazol-6-yl)methylene)-indolin-2-one except substituting 3-iodo-1H-indazole-6-carbaldehyde (462 mg, 1.70 mmol) and 1-methylindolin-2-one (250 mg, 1.70 mmol), (E)-3-((3-iodo-1H-indazol-6-yl)methylene)-1-methylindolin-2-one was obtained (yellow-orange solid, 545 mg, 80%); MS ESI 402.2 [M+H]+, calcd for [C17H12IN3O+H]+ 402.01.

Sources & evidence

ORD record
ord-07ad0baa25fc4987b888f77463990722
Source dataset
uspto-grants-2014_12
Patent number
US08921545B2

Reaction notes

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