HCID 178481470, compound → HCID 178481340, compound

HRID 1410348Notes

Reaction equation

HRID 1410348 reaction equation
[I:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C@H:11]3[C@@:13]4([C:21]5[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=5)[NH:15][C:14]4=[O:22])[CH2:12]3)=[CH:8][CH:9]=2)[NH:4][N:3]=1.I[C:24]1C2C(=CC(/C=C3/C(=O)N(C)C4C/3=CC=CC=4)=CC=2)NN=1>>[I:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C@H:11]3[C@@:13]4([C:21]5[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=5)[N:15]([CH3:24])[C:14]4=[O:22])[CH2:12]3)=[CH:8][CH:9]=2)[NH:4][N:3]=1

Participants

3

Reactant 2

HCID 178481470HCID 178481470, compoundHCID 178517040(1R*,2S*)-2-(3-iodo-1H-indazol-6-yl)-spiro[cyclopropane-1,3'-indolin]-2'-one

Product 1

HCID 178481340HCID 178481340, compound

Procedure

The title compound was synthesized according to the method of (1R*,2S*)-2-(3-iodo-1H-indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-one, except substituting (E)-3-((3-iodo-1H-indazol-6-yl)methylene)-1-methylindolin-2-one (545 mg, 1.36 mmol) to give the title compound as a 9:1 mixture of diastereomers (405 mg, 72%); MS ESI 416.0 [M+H]+, calcd for [C18H14IN3O+H]+ 416.03.

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-b05a049d8e2343179f9dec00d03f8dce
Source dataset
uspto-grants-2014_12
Patent number
US08921545B2

Reaction notes

Loading…