2,6-Difluorobenzoic acid → Sodium 2,6-difluorobenzoate

HRID 1410429Notes

Reaction equation

HRID 1410429 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+:13]>CCO.O>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([O-:6])=[O:5].[Na+:13]

Participants

5

Reactant 2

HCID 97962,6-Difluorobenzoic acidHCID 14798Sodium Hydroxide

Product 1

HCID 23698872Sodium 2,6-difluorobenzoateYield 100%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 2,6-difluorobenzoic acid (1.00 g, 6.3 mmol) in EtOH and water (5:1, 60 mL) was added 1N aqueous sodium hydroxide solution (6.33 mL, 6.3 mmol). The reaction mixture was stirred for 10 minutes at room temperature and then solvents were removed in vacuo to yield sodium 2,6-difluorobenzoate (1.22 g, 6.3 mmol, quantitative) as an off white solid. 1H NMR (DMSO) δ 6.89 (2H, m), 7.15 (1H, m).

Workup

  1. customsolvents were removed in vacuo

Sources & evidence

ORD record
ord-635760b542f24913a0acd03fb0071f95
Source dataset
uspto-grants-2014_12
Patent number
US08921544B2

Reaction notes

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