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4-Fluorocinnamic acid → 2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-[1-(trans-4-fluorocinnamoyl)-piperidin-4-yl]-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluorocinnamic acid | HCID 1530234 | — |
| 反応物 | 2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-piperidin-4-yl-acetamide dihydrochloride | HCID 67775194 | — |
| 生成物 | 2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-[1-(trans-4-fluorocinnamoyl)-piperidin-4-yl]-acetamide | HCID 57344296 | — |
反応手順
The title compound was prepared from the product of Example 1, step J (0.50 mmol), and trans-4-fluorocinnamic acid, by the method of Example 1, step K, giving the title compound as a white solid that was mostly the more polar cyclohexyl diastereomer by LCMS. Mass spectrum (LCMS, ESI pos.) calcd. for C30H35FN4O2: 503 (M+H). Found: 503
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08921559B2 |
| 出典データセット | uspto-grants-2014_12 |
| ORD ID | ord-e1e0460b909a4917b652a4d15ad8b3af |
| 出典メモ | uspto-grants-2014_12 |