HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Indanacrylic acid → 2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-[1-(trans-3-indan-5-ylprop-2-enoyl)piperidin-4-yl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Indanacrylic acid | HCID 6183612 | — |
| Reactant | 2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-piperidin-4-yl-acetamide dihydrochloride | HCID 67775194 | — |
| Product | 2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-[1-(trans-3-indan-5-ylprop-2-enoyl)piperidin-4-yl]-acetamide | HCID 57343818 | — |
Reaction Steps
The title compound was prepared from the product of Example 1, step J, and trans-3-indan-5-ylprop-2-enoic acid, by the method of Example 1, step K, giving a solid that was mostly the more polar cyclohexyl diastereomer by LCMS. Mass spectrum (LCMS, ESI pos.) calcd. for C33H40N4O2: 525 (M+H). Found: 525
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921559B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-13c60e2ef089402db30b1d65fd5236a3 |
| Source note | uspto-grants-2014_12 |