4-(Trifluoromethyl)cinnamic acid → 2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-[1-(trans-4-{trifluoromethyl}-cinnamoyl)piperidin-4-yl]-acetamide

Participants

Role	Name	HCID	Charge
Reactant	4-(Trifluoromethyl)cinnamic acid	HCID 688070	—
Reactant	2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-piperidin-4-yl-acetamide dihydrochloride	HCID 67775194	—
Product	2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-[1-(trans-4-{trifluoromethyl}-cinnamoyl)piperidin-4-yl]-acetamide	HCID 57344299	—

Reaction Steps

The title compound was prepared from the product of Example 1, step J, and trans-4-(trifluoromethyl)-cinnamic acid, by the method of Example 1, step K, giving a solid that was mostly the more polar cyclohexyl diastereomer by LCMS. Mass spectrum (LCMS, ESI pos.) calcd. for C31H35F3N4O2: 553 (M+H). Found: 553

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08921559B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-d693aae969924f798ee922839b17a1bb
Source note	uspto-grants-2014_12