Cinnamic Acid → HCID 57344218, compound

HRID 1410534Notes

Reaction equation

HRID 1410534 reaction equation
Cl.Cl.[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH:12]2[CH2:17][CH2:16][CH:15]([NH:18][CH:19]([CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[C:20]([NH2:22])=[O:21])[CH2:14][CH2:13]2)=[CH:4]1.[C:29](O)(=[O:38])/[CH:30]=[CH:31]/[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH:12]2[CH2:17][CH2:16][CH:15]([NH:18][CH:19]([CH:23]3[CH2:24][CH2:25][N:26]([C:29](=[O:38])/[CH:30]=[CH:31]/[C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[CH2:27][CH2:28]3)[C:20]([NH2:22])=[O:21])[CH2:14][CH2:13]2)=[CH:4]1

Participants

3

Reactant 2

HCID 444539Cinnamic AcidHCID 677751942-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-piperidin-4-yl-acetamide dihydrochloride

Product 1

HCID 57344218HCID 57344218, compound

Procedure

The title compound was prepared from the product of Example 1, step J, and trans-cinnamic acid, by the method of Example 1, step K, giving a solid that was a mixture of cyclohexyl diastereomers by LCMS. Mass spectrum (LCMS, ESI pos.) calcd. for C30H36N4O2: 484 (M+H). Found: 484

Workup

  1. customgiving a solid
  2. additiona mixture of cyclohexyl diastereomers by LCMS

Sources & evidence

ORD record
ord-e4bb95eaf40348c4b9e725f9266f296c
Source dataset
uspto-grants-2014_12
Patent number
US08921559B2

Reaction notes

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