3-[4-(Trifluoromethoxy)phenyl]acrylic acid → HCID 57344221, compound

HRID 1410535Notes

Reaction equation

HRID 1410535 reaction equation
Cl.Cl.[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH:12]2[CH2:17][CH2:16][CH:15]([NH:18][CH:19]([CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[C:20]([NH2:22])=[O:21])[CH2:14][CH2:13]2)=[CH:4]1.[F:29][C:30]([F:44])([F:43])[O:31][C:32]1[CH:42]=[CH:41][C:35](/[CH:36]=[CH:37]/[C:38](O)=[O:39])=[CH:34][CH:33]=1>>[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH:12]2[CH2:17][CH2:16][CH:15]([NH:18][CH:19]([CH:23]3[CH2:24][CH2:25][N:26]([C:38](=[O:39])/[CH:37]=[CH:36]/[C:35]4[CH:34]=[CH:33][C:32]([O:31][C:30]([F:43])([F:44])[F:29])=[CH:42][CH:41]=4)[CH2:27][CH2:28]3)[C:20]([NH2:22])=[O:21])[CH2:14][CH2:13]2)=[CH:4]1

Participants

3

Reactant 2

HCID 7358573-[4-(Trifluoromethoxy)phenyl]acrylic acidHCID 677751942-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-piperidin-4-yl-acetamide dihydrochloride

Product 1

HCID 57344221HCID 57344221, compound

Procedure

The title compound was prepared from the product of Example 1, step J, and trans-4-(trifluoromethoxy)cinnamic acid, by the method of Example 1, step K, giving a solid that was a mixture of cyclohexyl diastereomers by LCMS. Mass spectrum (LCMS, ESI pos.) calcd. for C31H35F3N4O3: 569 (M+H). Found: 569

Workup

  1. customgiving a solid
  2. additiona mixture of cyclohexyl diastereomers by LCMS

Sources & evidence

ORD record
ord-ce9e5e678aa5448cba43f45174ceda13
Source dataset
uspto-grants-2014_12
Patent number
US08921559B2

Reaction notes

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