HuagongsheHuagongshe Chemistry Print Report · For research reference only
trans-3,5-Difluorocinnamic acid → HCID 178501619, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | trans-3,5-Difluorocinnamic acid | HCID 5374941 | — |
| Reactant | Methyl 2-((4-(1H-indol-3-yl)cyclohexyl)amino)-2-(piperidin-4-yl)acetate | HCID 67774409 | — |
| Product | HCID 178501619 | HCID 178501619 | — |
Reaction Steps
The title compound was prepared from methyl 2-(4-(1H-indol-3-yl)cyclohexyl)amino)-2-(piperidin-4-yl)acetate (from Example 24, step A) and trans-3,5-difluorocinnamic acid, by the method of Example 1, step K, giving a solid that was mostly the more polar cyclohexyl diastereomer by LCMS. Mass spectrum (LCMS, APCI pos.) calcd. for C31H35F2N3O3: 536 (M+H). Found: 536.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921559B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-2ef06bb5c15e40cf9cccf8e4c244993d |
| Source note | uspto-grants-2014_12 |