HCID 49875950, compound → HCID 57344301, compound

HRID 1410538Notes

Reaction equation

HRID 1410538 reaction equation
Cl.Cl.[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH:12]2[CH2:17][CH2:16][CH:15]([NH:18][CH:19]([CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[C:20]([NH2:22])=[O:21])[CH2:14][CH2:13]2)=[CH:4]1.[O:29]1[C:38]2[C:33](=[CH:34][C:35](/[CH:39]=[CH:40]/[C:41](O)=[O:42])=[CH:36][CH:37]=2)[CH2:32][CH2:31][CH2:30]1>>[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH:12]2[CH2:17][CH2:16][CH:15]([NH:18][CH:19]([CH:23]3[CH2:24][CH2:25][N:26]([C:41](=[O:42])/[CH:40]=[CH:39]/[C:35]4[CH:34]=[C:33]5[C:38](=[CH:37][CH:36]=4)[O:29][CH2:30][CH2:31][CH2:32]5)[CH2:27][CH2:28]3)[C:20]([NH2:22])=[O:21])[CH2:14][CH2:13]2)=[CH:4]1

Participants

3

Reactant 2

HCID 49875950HCID 49875950, compoundHCID 677751942-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-piperidin-4-yl-acetamide dihydrochloride

Product 1

HCID 57344301HCID 57344301, compound

Procedure

The title compound was prepared from the product of Example 1, step J, and (2E)-3-(3,4-dihydro-2H-chromen-6-yl)prop-2-enoic acid, by the method of Example 1, step K, giving a yellow solid that was a mixture of cyclohexyl diastereomers by LCMS. Mass spectrum (LCMS, ESI pos.) calcd. for C33H40N4O3: 541 (M+H). Found: 541

Workup

  1. customgiving a yellow solid
  2. additiona mixture of cyclohexyl diastereomers by LCMS

Sources & evidence

ORD record
ord-ce47ea02918b4f1bb63f0daaa8b60a06
Source dataset
uspto-grants-2014_12
Patent number
US08921559B2

Reaction notes

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