3,4,5-Trifluorocinnamic acid → 2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-[1-(trans-3,4,5-trifluorocinnamoyl)-piperidin-4-yl]-acetamide

Participants

Role	Name	HCID	Charge
Reactant	3,4,5-Trifluorocinnamic acid	HCID 5708779	—
Reactant	2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-piperidin-4-yl-acetamide dihydrochloride	HCID 67775194	—
Product	2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-[1-(trans-3,4,5-trifluorocinnamoyl)-piperidin-4-yl]-acetamide	HCID 57344303	—

Reaction Steps

The title compound was prepared from the product of Example 1, step J, and trans-3,4,5-trifluorocinnamic acid, by the method of Example 1, step K, giving a yellow solid that was a mixture of cyclohexyl diastereomers by LCMS. Mass spectrum (LCMS, ESI pos.) calcd. for C30H33F3N4O2: 539 (M+H). Found: 539

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08921559B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-65a9dbb10be647fea991fe6b662f747f
Source note	uspto-grants-2014_12