3,4,5-Trifluorocinnamic acid → HCID 178501620, compound

Participants

Reaction Steps

The title compound was prepared from methyl 2-((4-(1H-indol-3-yl)cyclohexyl)amino)-2-(piperidin-4-yl)acetate (from Example 24, step A) and trans-3,4,5-trifluorocinnamic acid, by the method of Example 1, step K, and the mixture of product diastereomers was separated by flash chromatography giving a pale yellow solid for the more polar cyclohexyl diastereomer (trans, Example 49a), a tan solid for the less polar cyclohexyl diastereomer (cis, Example 49b). Mass spectrum (LCMS, APCI pos.) calcd. for C31H35F2N3O3: 536 (M+H). Found: 536.

Provenance & Evidence