6-Benzyl-1-oxa-6-azaspiro(2,5)octane → HCID 54673547, compound

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Reaction Steps

Referring to the method 2 of Example 1, N-benzyl-1-oxa-6-azaspiro[2,5]-octane and 5-bromo-2-hydroxy-pyridine were used for preparing a free base. Melting point: 146-148° C. The product was dissolved in ethanol-ethyl acetate and salified with HCl-EtOH to obtain a hydrochloride, yield 78.5%. Melting point: 148-150° C. 1H-NMR (D2O, ppm) δ: 7.594 (1H, d, J=2.80 Hz), 7.495 (1H, dd, J1=9.52 Hz, J2=2.52 Hz), 7.24-7.34 (5H, m), 6.365 (1H, d, J=9.52 Hz), 4.112 (2H, s), 3.891 (2H, s), 3.208 (2H, d, J=13.15 Hz), 3.031 (2H, t, J1=11.20 Hz, J2=12.60 Hz), 1.742 (2H, t×d, J1=11.20 Hz, J2=3.95 Hz), 1.573 (2H, J=14.57 Hz).

Provenance & Evidence