反应详情

A mixture of 1-benzyl-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carboxylic acid methyl ester (200 mg, 0.645 mmol) and bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate (0.83 g, 1.61 mmol) in 10 mL of CH2Cl2 was stirred at r.t. for 16 h. The mixture was diluted with CH2Cl2 and washed with dilute NaHSO3 and 1 M HCl. The organic layer was dried over MgSO4 and concentrated. The residue was purified by silica gel chromatography (100% CH2Cl2) to give 113 mg of the title compound as a pale yellow solid. MS: (+) m/z 437.13 (M+1).

1. washwashed with dilute NaHSO3 and 1 M HCl
2. dry with materialThe organic layer was dried over MgSO4
3. concentrationconcentrated
4. customThe residue was purified by silica gel chromatography (100% CH2Cl2)