HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1411136Generated: October 30, 2026
Ethyl 2-cyano-3-ethoxy-2-butenoate → Ethyl 2-cyano-5-(dimethylamino)-3-ethoxypenta-2,4-dienoate
https://huagongshe.com/reaction/1411136
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl 2-cyano-3-ethoxy-2-butenoate | HCID 46635 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Product | Ethyl 2-cyano-5-(dimethylamino)-3-ethoxypenta-2,4-dienoate | HCID 54113151 | — |
Reaction Steps
A mixture of ethyl 2-cyano-3-ethoxybut-2-enoate (194 g theory, 1.06 mol) and N,N-dimethylformamide dimethyl acetal (160 g, 1.325 mol) was heated at 70° C. for 2 h. The mixture was concentrated under high vacuum to provide crude ethyl 2-cyano-5-(dimethylamino)-3-ethoxypenta-2,4-dienoate. The residue was used directly without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08921565B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-5b52a943715c47558d5a1ac0346fc554 |
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| Source note | uspto-grants-2014_12 |
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