Hydrochloric Acid → Melphalan hydrochloride

Participants

Reaction Steps

In one embodiment of the present invention, the reaction of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine with hydrochloric acid in water is followed by concentration in presence of an organic solvent, stirring of the concentrated mixture with an alcohol, and separating the obtained solid to yield 4-[bis(2-chloroethyl)-amino]L-phenylalanine hydrochloride (I) of desired purity.

Provenance & Evidence