Methoxyacetyl chloride → (R)-5-chloro-N-(5-chlorothiazol-2-yl)-1'-(2-methoxyacetyl)spiro[indoline-3,3'-pyrrolidine]-1-carboxamide

Participants

Reaction Steps

The captioned compound was obtained in the form of a white solid by performing the same reactions and/or treatments as those in Example 3, with the exceptions that the (R)-5-chloro-N-(5-chlorothiazol-2-yl)spiro[indoline-3,3′-pyrrolidine]-1-carboxamide obtained as an intermediate of Example 52 was used instead of 5-bromo-N-(5-chlorothiazol-2-yl)spiro[indoline-3,3′-pyrrolidine]-1-carboxamide, and that methoxyacetyl chloride was used instead of acetyl chloride.

Provenance & Evidence