Methanol → HCID 90449400, compound

Participants

Reaction Steps

Methanol (10.7 mL), water (3.6 mL), and potassium carbonate (0.4 g, 2.86 mmol) were added to t-butyl 2-(5-chloro-1-(2,2,2-trifluoroacetyl)spiro[indoline-3,3′-pyrrolidin]-1′-yl)acetate (0.6 g, 1.43 mmol), and the obtained mixture was then stirred at room temperature for 1.5 hours. Thereafter, the reaction solution was diluted with ethyl acetate, and was then washed with water and brine. The organic layer was concentrated in vacuo to obtain t-butyl 2-(5-chlorospiro[indoline-3,3′-pyrrolidin]-1′-yl)acetate (0.47 g, >100%) in the form of a light brown oily product.

Provenance & Evidence