Ammonia methanol → HCID 90449917, compound

HRID 1411248Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:10]3([CH2:14][CH2:13][N:12]([CH2:15][C:16]([O:18]C)=O)[CH2:11]3)[CH2:9][N:8]([C:20](=[O:28])[NH:21][C:22]3[S:23][C:24]([Cl:27])=[CH:25][N:26]=3)[C:5]2=[CH:6][CH:7]=1.[CH3:29][NH2:30].O1CCCC1.N.CO>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:10]3([CH2:14][CH2:13][N:12]([CH2:15][C:16]([NH:30][CH3:29])=[O:18])[CH2:11]3)[CH2:9][N:8]([C:20]([NH:21][C:22]3[S:23][C:24]([Cl:27])=[CH:25][N:26]=3)=[O:28])[C:5]2=[CH:6][CH:7]=1

Participants

Reactant 3

HCID 21705897Ammonia methanol

HCID 66615946Methylamine tetrahydrofuran

HCID 90449729HCID 90449729, compound

Product 1

HCID 90449917HCID 90449917, compound

Procedure

The captioned compound was obtained in the form of a white solid by performing the same reactions and/or treatments as those in Example 45, with the exceptions that the methyl 2-(5-chloro-1-((5-chlorothiazol-2-yl)carbamoyl)spiro[indoline-3,3′-pyrrolidin]-1′-yl)acetate obtained in Example 58 was used instead of ethyl 2-(5-chloro-1-((5-chlorothiazol-2-yl)carbamoyl)spiro[indoline-3,3′-pyrrolidin]-1′-yl)-2-oxoacetate, and that a solution of methylamine-tetrahydrofuran was used instead of a saturated solution of ammonia-methanol.

Workup

customThe captioned compound was obtained in the form of a white solid

Sources & evidence

ORD record: ord-a6c8d7aee208493cbaa9af90813be17b
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921576B2

Reaction notes

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