Cyanoacetic acid → 5-chloro-N-(5-chlorothiazol-2-yl)-1'-(2-cyanoacetyl)spiro[indoline-3,3'-pyrrolidine]-1-carboxamide

Participants

Reaction Steps

The captioned compound was obtained in the form of a white solid by performing the same reactions and/or treatments as those in Example 23, with the exceptions that the 5-chloro-N-(5-chlorothiazol-2-yl)spiro[indoline-3,3′-pyrrolidine]-1-carboxamide obtained as an intermediate of Example 39 was used instead of 5-bromo-N-(5-chlorothiazol-2-yl)spiro[indoline-3,3′-pyrrolidine]-1-carboxamide, and that cyanoacetic acid was used instead of formic acid.

Provenance & Evidence