Imidazole → HCID 90449939, compound

Participants

Reaction Steps

2-((2-Aminothiazol-5-yl)thio)propan-1-ol (101 mg, 0.53 mmol) was dissolved in N,N-dimethylformamide (5 mL). Thereafter, imidazole (72 mg, 1.06 mmol) and t-butyldimethylsilyl chloride (100 mg, 0.64 mmol) were added to the above obtained solution, and the thus obtained mixture was then stirred at room temperature for 14.5 hours. Thereafter, the reaction solution was diluted with water, and was then extracted with ethyl acetate. The organic layer was washed with water and brine, and was then dried over anhydrous magnesium sulfate, followed by concentration in vacuo. The obtained residue was purified by preparative thin-layer chromatography (chloroform:methanol=10:1) to obtain 5-((1-((t-butyldimethylsilyl)oxy)propan-2-yl)thio) thiazole-2-amine (141 mg, 87%) in the form of a yellow oily product.

Provenance & Evidence