Hydrazine hydrate (1:1) → HCID 90449662, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 5-chloro-1-((5-((2-(1,3-dioxoisoindolin-2-yl)ethyl)thio)thiazol-2-yl)carbamoyl)spiro[indoline-3,3′-pyrrolidine]-1′-carboxylate (56 mg, 0.094 mmol) was dissolved in ethanol (3 mL). Thereafter, hydrazine monohydrate (0.007 mL, 0.14 mmol) was added to the above obtained solution, and the thus obtained mixture was then stirred at 90° C. for 3 hours. Thereafter, insoluble matters were removed by filtration, and the reaction solution was then concentrated in vacuo. The obtained residue was purified by preparative thin-layer column chromatography (chloroform:saturated ammonium methanol=10:1) to obtain the captioned compound (20 mg, 46%) in the form of a white solid.

Provenance & Evidence