Cyclopropanesulfonyl chloride → HCID 71523130, compound

HRID 1411263Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][CH2:4][S:5][C:6]1[S:10][C:9]([NH:11][C:12]([N:14]2[C:30]3[C:25](=[CH:26][C:27]([Cl:31])=[CH:28][CH:29]=3)[C:16]3([CH2:20][CH2:19][N:18]([C:21]([O:23][CH3:24])=[O:22])[CH2:17]3)[CH2:15]2)=[O:13])=[N:8][CH:7]=1.[CH:32]1([S:35](Cl)(=[O:37])=[O:36])[CH2:34][CH2:33]1>>[Cl:31][C:27]1[CH:26]=[C:25]2[C:16]3([CH2:20][CH2:19][N:18]([C:21]([O:23][CH3:24])=[O:22])[CH2:17]3)[CH2:15][N:14]([C:12](=[O:13])[NH:11][C:9]3[S:10][C:6]([S:5][CH2:4][CH2:3][CH2:2][NH:1][S:35]([CH:32]4[CH2:34][CH2:33]4)(=[O:37])=[O:36])=[CH:7][N:8]=3)[C:30]2=[CH:29][CH:28]=1

Participants

Reactant 2

HCID 2760919Cyclopropanesulfonyl chloride

HCID 90449488HCID 90449488, compound

Product 1

HCID 71523130HCID 71523130, compound

Procedure

The captioned compound was obtained in the form of a white solid by performing the same reactions and/or treatments as those in Example 3, with the exceptions that the methyl 1-((5-((3-aminopropyl)thio)thiazol-2-yl)carbamoyl)-5-chlorospiro[indoline-3,3′-pyrrolidine]-1′-carboxylate obtained in Example 176 was used instead of 5-bromo-N-(5-chlorothiazol-2-yl)spiro[indoline-3,3′-pyrrolidine]-1-carboxamide, and that cyclopropanesulfonyl chloride was used instead of acetyl chloride.

Workup

customThe captioned compound was obtained in the form of a white solid

Sources & evidence

ORD record: ord-c53ec86bd80346688b21a130339dbbdb
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921576B2

Reaction notes

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