5-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine → HCID 90449760, compound

HRID 1411267Notes

Reaction equation

HRID 1411267 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]2[S:9][C:10]([NH2:12])=[N:11][C:6]2=[CH:5][CH:4]=1.[C:13]([N:16]1[CH2:20][CH2:19][C:18]2([C:28]3[C:23](=[CH:24][CH:25]=[C:26]([O:29][CH2:30][CH3:31])[CH:27]=3)[N:22]([C:32](=[O:37])C(F)(F)F)[CH2:21]2)[CH2:17]1)(=[O:15])[CH3:14]>>[C:13]([N:16]1[CH2:20][CH2:19][C:18]2([C:28]3[C:23](=[CH:24][CH:25]=[C:26]([O:29][CH2:30][CH3:31])[CH:27]=3)[N:22]([C:32]([NH:12][C:10]3[S:9][C:7]4[C:6]([N:11]=3)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[N:8]=4)=[O:37])[CH2:21]2)[CH2:17]1)(=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 28015575-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amineHCID 90449559HCID 90449559, compound

Product 1

HCID 90449760HCID 90449760, compound

Procedure

The captioned compound was obtained in the form of a reddish brown solid by performing the same reactions and/or treatments as those in Step 4 of Example 198, with the exceptions that 5-methoxythiazolo[5,4-b]pyridin-2-amine was used instead of the 2-amino-5-chlorothiazole hydrochloride in Example 1, which was cited in Example 57, and that 1-(1′-acetyl-5-ethoxyspiro[indoline-3,3′-pyrrolidin]-1-yl)-2,2,2-trifluoroethanone was used instead of 1-(1′-acetyl-5-(4-fluorophenoxy)phenoxyspiro[indoline-3,3′-pyrrolidin]-1-yl)-2,2,2-trifluoroethanone.

Workup

  1. customThe captioned compound was obtained in the form of a reddish brown solid

Sources & evidence

ORD record
ord-0e7c52ce29404a52a164e63f72bc7860
Source dataset
uspto-grants-2014_12
Patent number
US08921576B2

Reaction notes

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