Methyl chloroformate → (S)-methyl 5-bromo-1-((5-((2-ethoxy-2-oxoethyl)thio)thiazol-2-yl)carbamoyl)spiro[indoline-3,3'-pyrrolidine]-1'-carboxylate

Participants

Reaction Steps

The captioned compound was obtained in the form of a white solid by performing the same reactions and/or treatments as those in Examples 1, 2, and 3, with the exceptions that (S)-t-butyl 5-bromospiro[indoline-3,3′-pyrrolidine]-1′-carboxylate was used instead of t-butyl 5-bromospiro[indoline-3,3′-pyrrolidine]-1′-carboxylate, that the ethyl 2-((2-aminothiazol-5-yl)thio)acetate synthesized by a method described in the known methods (International Publication WO2005/066145 etc.) was used instead of 2-amino-5-chlorothiazole hydrochloride, and that methyl chloroformate was used instead of acetyl chloride.

Provenance & Evidence