HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethoxalyl chloride → 5-Chloro-N-(5-fluorothiazol-2-yl)-1'-(2-(methylamino)-2-oxoacetyl)spiro[indoline-3,3'-pyrrolidine]-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethoxalyl chloride | HCID 20884 | — |
| Reactant | 5-Fluoro-1,3-thiazol-2-amine hydrochloride | HCID 11858931 | — |
| Reactant | Methylamine tetrahydrofuran | HCID 66615946 | — |
| Reactant | t-Butyl 5-cyanospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate | HCID 90449761 | — |
| Product | 5-Chloro-N-(5-fluorothiazol-2-yl)-1'-(2-(methylamino)-2-oxoacetyl)spiro[indoline-3,3'-pyrrolidine]-1-carboxamide | HCID 90449650 | — |
Reaction Steps
(t-Butyl 5-cyanospiro[indoline-3,3′-pyrrolidine]-1′-carboxylate, ethyl chloroglyoxylate, 2-amino-5-fluorothiazole hydrochloride, and a solution of methylamine-tetrahydrofuran)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921576B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-05a685bd15b24d48acd7b9098021d288 |
| Source note | uspto-grants-2014_12 |