HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethoxalyl chloride → 1'-(2-(Methylamino)-2-oxoacetyl)-N-(5-methylpyrazin-2-yl)-5-(trifluoromethyl)spiro[indoline-3,3'-pyrrolidine]-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethoxalyl chloride | HCID 20884 | — |
| Reactant | 5-Methylpyrazin-2-amine | HCID 313215 | — |
| Reactant | Methylamine tetrahydrofuran | HCID 66615946 | — |
| Reactant | tert-Butyl 5-(trifluoromethyl)spiro[indoline-3,3'-pyrrolidine]-1'-carboxylate | HCID 90449647 | — |
| Product | 1'-(2-(Methylamino)-2-oxoacetyl)-N-(5-methylpyrazin-2-yl)-5-(trifluoromethyl)spiro[indoline-3,3'-pyrrolidine]-1-carboxamide | HCID 90449649 | — |
Reaction Steps
(tert-Butyl 5-(trifluoromethyl)spiro[indoline-3,3′-pyrrolidine]-1′-carboxylate, ethyl chloroglyoxylate, 2-amino-5-methylpyrazine, and a solution of methylamine-tetrahydrofuran)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921576B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-a83d33fb92814a01af7a69bc880a48fd |
| Source note | uspto-grants-2014_12 |