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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1411282Generated: October 31, 2026

Ethoxalyl chloride → N-(5-Chlorothiazol-2-yl)-1'-(2-(methylamino)-2-oxoacetyl)-5-(trifluoromethyl)spiro[indoline-3,3'-pyrrolidine]-1-carboxamide

https://huagongshe.com/reaction/1411282

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthoxalyl chlorideHCID 20884—
Reactant2-Amino-5-chlorothiazole hydrochlorideHCID 148743—
ReactantMethylamine tetrahydrofuranHCID 66615946—
Reactanttert-Butyl 5-(trifluoromethyl)spiro[indoline-3,3'-pyrrolidine]-1'-carboxylateHCID 90449647—
ProductN-(5-Chlorothiazol-2-yl)-1'-(2-(methylamino)-2-oxoacetyl)-5-(trifluoromethyl)spiro[indoline-3,3'-pyrrolidine]-1-carboxamideHCID 90449812—

Reaction Steps

(tert-Butyl 5-(trifluoromethyl)spiro[indoline-3,3′-pyrrolidine]-1′-carboxylate, ethyl chloroglyoxylate, 2-amino-5-chlorothiazole hydrochloride, and a solution of methylamine-tetrahydrofuran)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08921576B2
Source datasetuspto-grants-2014_12
ORD IDord-5625264f09774624a0846f044b800709
Source noteuspto-grants-2014_12