5-Fluoro-1,3-thiazol-2-amine → (R)-5-chloro-N1-(5-fluorothiazol-2-yl)-N1'-methylspiro[indoline-3,3'-pyrrolidine]-1,1'-dicarboxamide

Participants

Reaction Steps

The captioned compound was obtained in the form of a white solid by performing the same reactions and/or treatments as those in Example 373, with the exceptions that the (S)-5-chloro-N-(5-chlorothiazol-2-yl)spiro[indoline-3,3′-pyrrolidine]-1-carboxamide obtained as an intermediate of Example 52 was used instead of 5-chloro-N-(5-chlorothiazol-2-yl)spiro[indoline-3,3′-pyrrolidine]-1-carboxamide, and that 2-amino-5-fluorothiazole was used instead of 2-amino-5-chlorothiazole hydrochloride.

Provenance & Evidence