Difluoroacetic acid → 5-Chloro-N-(5-chlorothiazol-2-yl)-1'-(2,2-difluoroacetyl)spiro[indoline-3,3'-pyrrolidine]-1-carboxamide

HRID 1411284Notes

Reaction equation

HRID 1411284 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:10]3([CH2:14][CH2:13][NH:12][CH2:11]3)[CH2:9][N:8]([C:15]([NH:17][C:18]3[S:19][C:20]([Cl:23])=[CH:21][N:22]=3)=[O:16])[C:5]2=[CH:6][CH:7]=1.[F:24][CH:25]([F:29])[C:26](O)=[O:27]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:10]3([CH2:14][CH2:13][N:12]([C:26](=[O:27])[CH:25]([F:29])[F:24])[CH2:11]3)[CH2:9][N:8]([C:15]([NH:17][C:18]3[S:19][C:20]([Cl:23])=[CH:21][N:22]=3)=[O:16])[C:5]2=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 9788Difluoroacetic acidHCID 904492715-chloro-N-(5-chlorothiazol-2-yl)spiro[indoline-3,3'-pyrrolidine]-1-carboxamide

Product 1

HCID 904497495-Chloro-N-(5-chlorothiazol-2-yl)-1'-(2,2-difluoroacetyl)spiro[indoline-3,3'-pyrrolidine]-1-carboxamide

Procedure

5-Chloro-N-(5-chlorothiazol-2-yl)spiro[indoline-3,3′-pyrrolidine]-1-carboxamide and difluoroacetic acid

Sources & evidence

ORD record
ord-4b06e7db588340ac95dad3cce60cd6f4
Source dataset
uspto-grants-2014_12
Patent number
US08921576B2

Reaction notes

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